How Much CBD Oil Would it Take to Kill You?
Whether you know your chemistry and/or toxicology, however, you will know that somewhere there is a fatal cutoff point. In addition, all chemical substances are potentially lethal if ingested at a dosage sufficiently high. When we drink too much in too short a time, only water can be lethal to humans.
However, given that Epidiolex (a CBD-based epilepsy drug) has just become the first ever prescription cannabis medication to receive FDA approval, more and more people are curious about what CBD oil's toxicity level is. In other words, what amount of CBD oil would you need to kill you?
In this article, we aim to answer exactly that question.
First Things First: What is Toxicity?
The FDA requires that all approved drugs develop a level of toxicity, or what is known as an LD50. The LD50 (LD means "lethal dose") of any chemical compound is the amount it would take to kill at a certain dosage 50 percent of test subjects. As per the FDA (females are more prone to toxic effects than males) the "test subjects" are female rats. Some animal species will normally, though, be enough.
For example, if 100 rats ingest 1,000 mg of ibuprofen and the dose proves lethal for 50 of them, we might accurately say that the ibuprofen LD50 is 1,000 mg (this is a loose generalization, and not the actual ibuprofen LD50).
Clinical trials for an FDA-approved drug need not reveal an LD50, to be sure. There simply has to be clear pre-existing scientific evidence which establishes some sort of compound toxicity. As such, the latest Epidiolex approval did not reveal either an LD50 or a level of human toxicity to CBD. Nevertheless, some previous studies have attempted to establish a level of cannabidiol (CBD) and9-tetrahydrocannabinol (THC) for both.
How Much CBD Would it Take to Kill You?
In addition, Toxicology Data Network of the government lists rates of toxicity for CBD (otherwise known as cannabidiol, the active ingredient in Epidiolex). In addition, there are three distinct LD50s from three different studies spanning more than 70 years. The LD50 for cannabidiol in dogs was estimated to exceed 254 mg per kg body weight when administered intravenously (1946) An LD50 was identified in mice at 50 mg per kg body weight when administered intravenously (1975)
A report in Toxicology and Applied Pharmacology showed the LD50 for CBD to be 212 mg per kg of body weight when administered intravenously in monkeys (1981) More recently, a 2011 article in Current Drug Safety observed toxic levels of CBD in rhesus monkeys when administered orally. Doses of more than 200 mg per kg of body weight proved fatal in some monkeys by respiratory arrest and heart failure, whereas 300 mg per kg of body weight resulted in "rapid death."
Consider a person of relatively average height at 75 kg (approx. 165 lbs) for comparison. By these figures, it would take approximately 18,750 mg (18.75 g) of CBD ingested within a very short time to produce any potentially fatal impact. By contrast, most common consumers of CBD oil eat no more than 100 mg of the compound— and that's the whole day.
What does the data mean?
The report estimates that an LD50 for marijuana extract is higher than 10,000 mg per kg of body weight in primates, according to those statistics.
Finally, the “8-Factor Analysis on Cannabis” by the FDA illustrates the argument of the Americans for Safe Access (ASA) that no known LD50 exists for any type of marijuana in humans. It includes quotes from any of the major components.
The study underlined the fact that researchers unsuccessfully attempted to establish a reliable LD50 level for cannabis in animals for years. Another assertion in the study stated that “researchers have continuously been unable to give animals enough natural cannabis to induce a death.” However, according to current ASA estimates, a marijuana user would have to ingest 20,000 to 40,000 times the amount of cannabis in a typical marijuana cigarette (defined by the National Drug Abuse Institute as 0.9 g) in order to experience any potentially fatal cigarette. For reference, this would be approximately 1,500 lbs of cannabis within a 15-minute period to induce a “theoretically lethal response.”
Final Thoughts on CBD Oil Toxicity Levels
There is no correctly defined lethal dose of CBD oil in humans, to be sure. As demonstrated by WHO and other organizations, the compound is a healthy and non-addictive drug. It may have profound therapeutic effects on a number of physiological disorders, in addition. That being said, talking to a doctor before adding CBD to your healthcare routine is always wise. CBD inhibits cytochrome p-450 enzyme activity which can influence how the body metabolizes such drugs. Using CBD responsibly, exercise protection and patience and your body will be grateful in the long run.
When it comes to purchasing quality CBD Gummies that are both delicious and effective, you always want to make sure the products you are receiving come from a reputable source like Mary Jane’s CBD Dispensary. The main reason for picking products like ours is to ensure you only get the best quality CBD products and never receive any ineffective and/or potentially harmful products. With locations across several states to serve you, and our convenient online store, when you shop with Mary Jane’s you know you will only get the best CBD products on the market today.